Trazodone is an antidepressant drug that’s prescribed to treat the symptoms of depression.
Trazodone is in a class of medications called serotonin modulators, which work by moderating levels of serotonin (a neurotransmitter ) in the brain.
The Food and Drug Administration (FDA) first approved trazodone in 1981 under the brand name Desyrel.
Trazodone is now available as a generic drug, and multiple drug companies produce it.
The only brand name remaining for this drug is Oleptro.
Besides treating depression, doctors may also prescribe trazodone to treat anxiety, schizophrenia, or uncontrolled movements that occur as a side effect of other medications.
Trazodone for Insomnia Your doctor may prescribe trazodone to treat insomnia or other sleep disorders.
A study in the American Journal of Geriatric Psychiatry in 2014 found the drug to be very effective in treating sleep disturbances in people with Alzheimer’s disease.
Trazodone improved nighttime sleep but did not affect thinking or brain function.
Taking the drug did not lead to daytime sleepiness or naps.
Trazodone Warnings The FDA requires a black-box warning on trazodone, noting that taking the drug could increase the chance of becoming suicidal.
The risk of suicide is greatest when starting treatment or when increasing or decreasing the dose of trazodone.
Suicide risk may be higher for people younger than 24.
Depression may become worse before it gets better when someone starts taking trazodone.
Your doctor will watch you carefully for symptoms of aggression, irritability, panic attacks, extreme worry, restlessness, acting without thinking, abnormal excitement, or any thoughts of suicide when you start the drug.
You should also let friends and family members know if you have these symptoms or worsening symptoms of depression.
If you have any thoughts of suicide or if a friend or family member thinks you are acting strangely, call a doctor right away.
Stopping trazodone suddenly can cause withdrawal symptoms that include anxiety, agitation, and difficulty sleeping.
Children or teens should not take trazodone.
Tell your doctor if you have: Heart problems Low or high blood pressure History of substance abuse Any mental health disorders Cancer Anemia Liver problems Kidney problems Diarrhea or vomiting Anyone taking the drug should let their doctor know about any family history of suicide.
If you are a man, let your doctor know if you have any problem with an erection that will not go away (priapism).
It’s important to tell your doctor if you have symptoms of aggression, irritability, panic attacks, extreme worry, restlessness, acting without thinking, abnormal excitement, or any thoughts of suicide while on trazodone.
Trazodone ‘High’ and Abuse Because trazodone isn’t regulated as strictly as other sleep medications, it has some potential for abuse by people seeking a high.
The drug has been anecdotally linked to hallucinations in high doses, but the risks of overdose and severe side effects make this a very dangerous recreational drug.
Take trazodone only as directed, and keep this and all other drugs away from children, teenagers, and anyone for whom the drug has not been prescribed.
Pregnancy and Trazodone Trazodone may cause harm to a developing fetus.
Some animal studies have found evidence of developmental abnormalities in fetuses that were exposed to the drug.
It’s not known if trazodone is safe for breastfeeding infants.
You should speak to your doctor about using trazodone before breastfeeding, and if you are or might be pregnant.
BasicDescription Back to Top Trazodone Side Effects Common side effects of trazodone include: Headache Muscle ache Nausea, vomiting, loss of appetite, or stomachache Constipation or diarrhea Loss of interest in sex ( erectile dysfunction in men) Dizziness or loss of balance Dry mouth or dry eyes Numbness, burning, or tingling sensations Confusion Blurred vision Ringing in the ears Nervousness or confusion Rash Sweating Weakness or fatigue Serious side effects can occur.
If you have any of these side effects, stop taking trazodone and call your doctor right away: Worsening depression Suicidal thoughts A severe rash or hives Swelling of the face, lips, or tongue Chest pain Difficulty breathing A painful erection that will not go away (priapism) Panic attack Irregular heartbeat Fainting Unusual bruising or bleeding Seizure Trazodone also might cause some people to have auditory hallucinations while taking the drug.
However, evidence of this is preliminary and needs further investigation.
Back to Top Trazodone Interactions Many drugs may affect the way trazodone works, and trazodone may affect other drugs you are taking and cause problems.
It’s very important to let your doctor know about all drugs you are taking, including illegal drugs and any over-the-counter (OTC) herbs or supplements.
Types of drugs that are known to interact with trazodone include: Blood thinners, including warfarin (Coumadin), aspirin, and ibuprofen Drugs used to treat mental illness, including thioridazine ; selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine ( Prozac, Sarafem) and fluvoxamine ( Luvox ); and MAOIs such as isocarboxazid (Marplan) and phenelzine (Nardil) Diuretics Cold, cough, and allergy medications, including dexamethasone (Decadron) Medications used to treat fungal diseases, such as ketoconazole (Nizoral), itraconazole (Sporanox), and (Vfend) Medications used to treat HIV/AIDS, including atazanavir (Reyataz), indinavir (Crixivan), and nelfinavir (Viracept) Medications used to treat heartburn, including cimetidine (Tagamet) and cisapride (Propulsid) Some antibiotics, such as clarithromycin (Biaxin, in Prevpac) and erythromycin (E.E.S., E-Mycin, Erythrocin) Some heart medications, including sotalol (Betapace, Betapace AF) and verapamil (Calan, Isoptin, Verelan) Some seizure medications, such as carbamazepine ( Tegretol ), ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin ( Dilantin ) Trazodone may make you feel drowsy and may affect your judgment.
Until you know how trazodone will affect you, don’t drive or operate machinery.
Drinking alcohol may make some side effects of trazodone more severe and cause problems.
Back to Top Trazodone Dosage Trazodone is an oral drug, which is available as a regular-release or extended-release tablet.
The tablets have a score line, or indentation down the middle.
Depending on the dose your doctor prescribes, you may need to break a tablet in half.
Do not crush, snort, or chew a tablet.
Your doctor will start you on a low dose of trazodone and increase the dose every three to four days.
It may take up to two weeks before you notice a response.
A daily dose of trazodone may range from 150 to 375 milligrams.
Take regular tablets two or more times a day with food.
If your doctor prescribes an extended-release tablet, you’ll take it once a day at bedtime on an empty stomach.
Trazodone Overdose Symptoms of a trazodone overdose may include: Vomiting Drowsiness Painful erection Abnormal heartbeat Trouble breathing Seizures If you or someone else has symptoms of an overdose, call a poison control center at 1-800-222-1222.
If someone collapses or isn’t breathing, call 9-1-1 immediately.
Missed Dose of Trazodone Take trazodone exactly as directed by your doctor.
Don’t stop taking trazodone on your own because stopping suddenly can cause withdrawal symptoms that include anxiety, agitation, and difficulty sleeping.
If you miss a dose of trazodone, take the missed dose as soon as you remember.
If it’s almost time for your next dose, skip the missed dose.
Don’t double your dose to make up for a missed dose.
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