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Celecoxib is a prescription medication used to treat pain, arthritis, and painful menstrual periods. Celecoxib belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). These work by blocking chemicals in the body that cause pain and inflammation.
Celecoxib comes in capsule form and is taken by mouth, once or twice daily, with or without food.
Common side effects include stomach pain, upset stomach, and diarrhea.
CYP2C9 is a protein in your body that is involved in the elimination of celecoxib and other drugs from your body. Some patients have less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2C9 can vary greatly between individuals, and those having less of this protein are known as “poor metabolizers.”
CYP2C9 testing is done to determine whether you are a poor metabolizer. If you are a poor metabolizer, the levels of celecoxib in your blood can become too high. As a result you may be at an increased risk of having more side effects from celecoxib.
Your doctor may adjust your dose of celecoxib if you are a poor metabolizer.
Moreover, if the particles were milled when formulated, then the needle-shaped structure of celecoxib particles was destroyed and, hence, the appellant’s argument was no longer valid.
Patients with severe hepatic impairment (serum albumin The pharmacokinetics of celecoxib has not been studied in patients with renal impairment but is unlikely to be markedly changed in these patients.
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In patients with OA, treatment with celecoxib 100 mg twice daily or 200 mg once daily resulted in improvement in WOMAC (Western Ontario and McMaster Universities) osteoarthritis index, a composite of pain, stiffness, and functional measures in OA.
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