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Additional information about the drug Felodipine


Felodipine is a medication of the calcium channel blocker type which is used to treat high blood pressure.
Contents
1 Medical uses
2 Adverse effects
3 Interactions
4 Mechanism of action
5 Chemistry
6 History
7 Society and culture
8 References
Medical uses
Felodipine is used to treat high blood pressure and stable angina.
It should not be used for people who are pregnant, have acute heart failure, are having a heart attack, have an obstructed heart valve, or have obstructions that block bloodflow out of the heart.
For people with liver failure the dose needs to be lowered, because felodipine is cleared by the liver.
Adverse effects
The only very common side effect, occurring in more than 1/10 people, is pain and swelling in the arms and legs.
Common side effects, occurring in between 1% and 10% of people, include flushing, headache, heart palpitations, dizziness and fatigue.
Felodipine can exacerbate gingivitis.
Interactions
Felodipine is metabolized by cytochrome P450 3A4, so substances that inhibit or activate CYP3A4 can strongly effect how much felodipine is present.
CYP3A4 inhibitors, which increase the amount of felodipine available per dose, include cimetidine, erythromycin, itraconazole, ketoconazole, HIV protease inhibitors, and grapefruit juice.
CYP3A4 activators, which decrease the amount of felodipine available per dose, include phenytoin, carbamazepine, rifampicin, barbiturates, efavirenz, nevirapine, and Saint John’s wort.
Mechanism of action
Felodipine is a calcium channel blocker.
Different calcium channels are present in vascular tissue and cardiac tissue; an in vitro study on human vascular and cardiac tissues comparing how selective various calcium channel blockers are for vascular compared to cardiac tissue found the following vascular/cardiac tissue ratios: mibefradil 41, felodipine 12; nifedipine 7, amlodipine 5, and verapamil 0.2. : 172
Chemistry
Felodipine is a member of the 1,4- dihydropyridine class of calcium channel blockers. : 25
History
The Swedish company Hässle, a division of Astra AB, discovered felodipine;
In 1994 Astra AB and Merck changed their partnership to a joint venture called Astra Merck,
The first generics became available in Sweden in 2003 : 155
In April 2016, AstraZeneca announced that they were selling the right to market felodipine in China to China Medical System Holdings for $310 million; AZ would continue to manufacture the drug.
Society and culture
As of 2016, felodipine was marketed under many brand names worldwide: Auronal, Cardioplen, Catrazil, Dewei, Dilahex, Enfelo, Erding, Fedil, Fedisyn, Feldil, Felicipin, Felo, Felocard, Felocor, Feloday, Felodil, Felodin, Felodip, Felodipin, Felodipina, Felodipine, Felodipino, Felodistad, Felogard, Felohexal, Felop, Felopine, Felostad, Feloten, Felotens, Felpin, Flodicar, Flodil, Keliping, Keydipin, Lodistad, Modip, Munobal, Nirmadil, Parmid, Penedil, Perfudal, Phelop, Phenodical, Plendil, Plentopine, Polo, Presid, Preslow, Prevex, Renedil, Sistar, Splendil, Stapin, Topidil, Vascalpha, Versant, and XiaoDing.
The combination of felodipine and candesartan was marketed as Atacand.
The combination of felodipine and ramipril was marketed as Delmuno, Tazko, Triacor, Triapin, Triasyn, Tri-Plen, Unimax, and Unitens.
The combination of felodipine and enalapril was marketed as Lexxel.
The combination of felodipine and metoprolol was marketed as Logimat, Logimax, and Mobloc.

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