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Effexor, formerly sold as Effexor, is a prescription drug used to treat depression, anxiety, social phobia, and panic disorder.
The brand name Effexor has been discontinued in the United States, though Effexor XR and generic venlafaxine are available.
Effexor belongs to the class of antidepressants called serotonin-norepinephrine reuptake inhibitors (SNRIs).
SNRIs work by increasing the brain’s levels of serotonin and norepinephrine, neurotransmitters that act together to brighten mood and relieve pain.
Made by Pfizer, the Food and Drug Administration (FDA) approved Effexor in pill form in 1993 for the treatment of depression, and in extended-release capsules, called Effexor XR, in 1997.
It approved Effexor for generalized anxiety disorder (GAD) in 1999, social anxiety disorder in 2003, and for panic disorder in 2005.
The generic version of Effexor, venlafaxine, was approved in 2010.
Effexor has also been prescribed off-label to treat hot flashes brought on by menopause or therapy for breast cancer ; pain tied to diabetic nerve damage; post-traumatic stress disorder (PTSD) ; debilitating migraines and tension-type headaches; chronic fatigue syndrome; bipolar depression; and attention-deficit hyperactivity disorder (ADHD).
Effexor Warnings The FDA has issued a black-box warning for venlafaxine because studies found an increased risk of suicidal thoughts and behavior in children, teenagers, and young adults taking antidepressants, including Effexor.
Effexor can interact with other prescription or nonprescription medications in ways that hinder its effectiveness or bring on serious side effects.
Tell your doctor if you are taking other antidepressants, including such selective serotonin uptake inhibitors (SSRIs) as Paxil ( paroxetine ) or Zoloft (sertraline), other SSNRIs such as Cymbalta (duloxetine) or Pristiq (desvenlafaxine), or any monoamine oxidase inhibitors (MAOIs), including Nardil (phenelzine) or Marplan (isocarboxazid), or whether you stopped taking an MAOI within 14 days of beginning venlafaxine.
You also need to inform your healthcare provider if you take so-called tripan medications such as sumatriptan ( Imitrex, Imigran) for migraines, certain painkillers such as Utram ( tramadol ), the antibiotic linezolid ( Zyvox ), or intravenous methylene blue, which is used to treat the blood disorder methemoglobinema.
These medications, along with the herbal supplement St.
John’s wort, raise the level of serotonin in the brain, and when taken in tandem with venlafaxine can trigger a rare but potentially life-threatening condition called serotonin syndrome.
Effexor might also enhance the anti-blood-clotting effect of such blood thinners as warfarin ( Coumadin, Jantoven), as well as aspirin, and non-steroidal anti-inflammatory drugs (NSAIDs), including ibuprofen (Advil, Motrin).
Effexor Withdrawal If you stop taking venlafaxine suddenly, or reduce your dosage, withdrawal symptoms can occur, often within a matter of hours.
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Elderly patients may be at greater risk of developing hyponatremia with SSRIs and SNRIs.Effexor Extended Release Tablets, like many antidepressants, should be used cautiously in patients with a history of seizures and should be discontinued in any patient who develops seizures. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anticoagulants may add to this risk.
Below is a list of the patient’s medications, his physical examination, and his laboratory findings: How would you proceed, and how you would monitor for efficacy and toxicity? Include precise mechanism(s) of how it is occurring. Explain why the SSRI should be slowly discontinued prior to starting bupropion in Part Three. In your answer, be sure to compare and contrast bupropion with each medication mentioned above (fluoxetine, venlafaxine, and nortriptyline).
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