Prograf is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received kidney, liver, or heart transplants. It is also used as a topical agent for treating eczema that has not responded to other medications.
Prograf is in a class of medications called immunosupressants. It works by decreasing the activity of the immune system.
This medication comes in an immediate-release capsule form that is taken twice a day and extended-release capsule and tablet forms that are taken once a day. It is also available as an injectable form that is given as an ongoing infusion after the transplant surgery.
Prograf is also available as a topical ointment that is applied to the affected skin twice a day.
Common side effects of oral and injectable tacrolimus include infection, altered renal function, increased blood pressure, headache, tremor, and nausea. Common side effects of topical tacrolimus include soreness or irritation at the application site.
Prograf can also cause blurred vision, drowsiness, and dizziness. Do not drive or operate heavy machinery until you know how tacrolimus affects you.
Prograf is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received kidney, liver, or heart transplants. It works by decreasing the activity of the immune system to prevent it from attacking the transplanted organ.
Prograf is used for treating eczema that has not responded to other medications. It works by stopping the immune system from producing substance that may cause eczema.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Prograf may be found in some form under the following brand names:
Prograf is part of the drug class:
Serious side effects have been reported with Prograf. See the “Prograf Precautions” section.
Common side effects of oral and injectable tacrolimus include the following:
Common side effects of topical tacrolimus include the following:
This is not a complete list of tacrolimus side effects. Ask your doctor or pharmacist for more information.
Because those in infancy or early childhood are at high risk for steroid-induced elevation of intraocular pressure, tacrolimus eye drops may be a very effective, alternative treatment for VKC or AKC that does not impose the risk of developing glaucoma. However, a previous study examining cyclosporine 0.1% aqueous ophthalmic solution showed a similar incidence of corneal infection, in which 5 (0.84%) of 594 patients developed infectious corneal complications (bacterial corneal ulcer (two cases), herpetic keratitis (three cases)). 17 This suggests that tacrolimus eye drops are equivalent to cyclosporine for the indications studied here. This is likely because the percentage of tacrolimus reaching the bloodstream with twice-daily topical use is very low. 21, 22 In conclusion, we evaluated the efficacy and safety of tacrolimus eye drops in patients with VKC or AKC in a clinical setting.
The participants were given topical therapy after normal clinical practice, mainly topical corticosteroids and tacrolimus 0.03% or 0.1%. They were enrolled for up to 6 months, or until the target PG ulcer had healed.
The serum concentration of Prograf can be decreased when it is combined with Pitolisant.
Venkataramanan, R., Shaw, L.M., Sarkozi, L., et al. Clinical Utility of Monitoring Prograf Blood Concentrations in Liver Transplant Patients.
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