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Levaquin is the brand name for levofloxacin, a prescription antibiotic drug used to treat a variety of bacterial infections, such as: Pneumonia Acute bacterial sinusitis Chronic bronchitis worsened by bacterial infections Skin infections Chronic prostate gland infection (prostatitis) Urinary tract infection (UTI) Acute kidney infection Inhalational anthrax, or anthrax contracted by breathing in anthrax spores Pneumonic and septicemic plague (Levaquin is also used to prevent contracting plague ) Levaquin belongs to a class of antibacterial agents called fluoroquinolones, which kill bacteria by inhibiting the activity of certain enzymes bacteria require to replicate, transcribe, repair, and recombine DNA.
Doctors may also prescribe Levaquin “off-label” to treat or prevent other bacterial infections, including tuberculosis (TB), Salmonella food poisoning, Shigella food poisoning, Campylobacter infections, and disseminated Mycobacterium avium complex disease, especially for people with a weakened immune system from HIV or other conditions.
Levaquin was first approved by the Food and Drug Administration (FDA) in 1996, and is produced by Janssen Pharmaceuticals, Inc, a subsidiary of Johnson & Johnson.
Levaquin and Tendon Issues In 2008, the FDA required all fluoroquinolone manufacturers to include a black-box warning that the drug class can increase a person’s risk of tendonitis (tendon inflammation) and tendon rupture, a decision that came too late for a lot of people taking Levaquin, resulting in numerous lawsuits.
Plaintiffs charge that Johnson & Johnson should have strengthened their warnings about the potential tendon issues associated with Levaquin before the FDA issued its decree, and also that the company downplayed the drug’s risks to boost sales.
In 2010, Johnson & Johnson lost a court case against 87-year-old John Schedin, and had to pay nearly $2 million to Schedin for the damage he received to his Achilles tendon after taking Levaquin.
The company subsequently won several other court cases, in which plaintiffs failed to show the drug caused their tendon issues.
Chloroquine: (Major) Concurrent use of chloroquine and levofloxacin should be avoided due to an increased risk for QT prolongation and torsade de pointes (TdP).
Although azithromycin, clarithromycin, and levofloxacin are frequently used for the treatment of respiratory C. pneumoniae infections, little is known about the dose and duration of therapy needed to treat a putative chronic C. pneumoniae infection.
Levofloxacin is not useful for prophylaxis in contacts.
Combined bacitracin-polymyxin ointment is often used prophylactically after corneal foreign body removal for the protection it affords against both grampositive and gram-negative organisms. Among the most effective broad-spectrum antibiotics for ophthalmic use are fluoroquinolones (ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, moxifloxacin, and gatifloxacin), gentamicin, tobramycin, and neomycin.
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