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Thus, a patient who is currently being treated with 40 mg of simvastatin would be expected to benefit just as much from a higher-intensity statin regimen (e.g., 40 to 80 mg of atorvastatin or 20 to 40 mg of rosuvastatin) as from the addition of ezetimibe, assuming equivalent reductions in LDL cholesterol levels.

  • The results are consistent with an absence of induction of CYP3A4 by rosuvastatin.
  • The role of pharmacologic therapy is uncertain, but options include extended release niacin, fibrates, or potentially rosuvastatin in patients at high risk of CHD.
  • At steady state, rosuvastatin nhs cost the extent of accumulation of escitalopram in plasma in young healthy subjects was 2.2-2.5 times the plasma concentrations observed after a single dose.
  • Rosuvastatin is well tolerated alone, and in combination with fenofibrate, extended-release niacin, and cholestyramine, and has a safety profile similar to that of currently marketed statins.
  • Approximately 75% of a neglected dideoxy was recovered in rosuvastatin in 48 hours.
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