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Additional information about the drug Capecitabine

Xeloda – Capecitabine – 500mg – Cancer

Capecitabine 500mg – xeloda “Cancer, Chemotherapy, Breast Cancer”

Capecitabine is a prescription medication used to treat breast cancer and cancer of the colon or rectum. Capecitabine belongs to a group of drugs called antimetabolites which work by interfering with DNA production, stopping cells from multiplying.
This medication comes in tablet form and is usually taken twice daily, within 30 minutes after the end of a meal.
Swallow tablets whole. Do not cut or crush tablets.
Common side effects include diarrhea, nausea, vomiting, and mouth sores.
DPD is the enzyme responsible for breaking down capecitabine in the body. Some patients lack the DPD enzyme. If you lack or have less of the DPD enzyme, you may be more likely to experience side effects more quickly or severely once you begin treatment with capecitabine. Tell your doctor if you have ever been told you lack the DPD enzyme.
Your doctor may decide to temporarily or permanently stop treatment with capecitabine depending on the severity of side effects. There are no exact dosing guidelines based on the results of any particular DPD test.
In tumor cells with high proliferative activity, the concentration of the key enzyme for this transformation, thymidine phosphorylase, is essentially higher than in non-malignant tissues, supporting a specific antitumor activity of capecitabine.

  • Remaining patients were treated with chemoradiation consisting of intensity modulated radiation therapy (54 Gy) and concurrent capecitabine; patients with borderline resectable disease or better at restaging underwent attempted resection.
  • Calcium folinate increases toxicity of capecitabine due to increased toxicity of fluorouracil.
  • The objective of this clinico-pathology study was to determine the correlation between TP expression in the tumor tissue and the clinical outcome to capecitabine based therapy in patients with locally advanced or metastatic breast cancer.
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